B7-H4 (human) (rec.)

General

Product specifications for - B7-H4 (human) (rec.)

Overview:
Product group:	Proteins / Signaling Molecule
Category:	Proteins
Subcategory:	Recombinant protein
Source:	HEK 293 cells

Properties:
Purity:	>95% (SDS-PAGE)
Molecular weight:	50 kDa
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352202
Form supplied:	Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions:	Store at -20°C

Scientific information:
Scientific info:	B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
Swiss prot ID:	NP_078902.2

Scientific information:

Scientific info:

B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.

Swiss prot ID:

NP_078902.2

Additional information:
Synonyms:	CHI-HF-200B7H4-C050; Chimerigen Laboratories

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Product specifications for - B7-H4 (human) (rec.)