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B7-H4 (human) (rec.)
Catalog number:
CHI-HF-200B7H4-C050
Brand:
Chimerigen Laboratories
Packing:
50 ug
Price:
€ 330.00
Expected delivery time:
7 days
Quantity:
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General
Product specifications for - B7-H4 (human) (rec.)
Overview:
Product group:
Proteins / Signaling Molecule
Category:
Proteins
Species:
Human
Properties:
Purity:
>95% (SDS-PAGE)
Molecular weight:
~50kDa (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352202
Form supplied:
Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance. - Protein. The extracellular domain of human B7-H4 (aa 29-258). Source: HEK 293 cells. Endotoxin content: <0.01EU/microg protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in PBS. Purity: >95% (SDS-PAGE). B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
Safety information:
Hazard information:
Non-hazardous
Additional information:
Synonyms:
CHI-HF-200B7H4-C050; Chimerigen Laboratories