B7-H4 (human) (rec.)

Catalog number: CHI-HF-200B7H4-C050
Brand: Chimerigen Laboratories
Packing: 50 ug
Price: € 320.00
Expected delivery time: 7 days
Quantity:

Product specifications for - B7-H4 (human) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: HEK 293 cells
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: 50 kDa
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
Swiss prot ID: NP_078902.2
Additional information: 
Synonyms: CHI-HF-200B7H4-C050; Chimerigen Laboratories