B7-H4 (human):Fc (mouse) (rec.)

Catalog number: CHI-HF-211B7H4-C100
Brand: Chimerigen Laboratories
Packing: 100 ug
Price: € 360.00
Expected delivery time: 7 days

Product specifications for - B7-H4 (human):Fc (mouse) (rec.)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: CHO cells
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
Swiss prot ID: NP_078902.2
Additional information: 
Synonyms: CHI-HF-211B7H4-C100; Chimerigen Laboratories; VTCN1 / B7-H4; VTCN1; VCTN1; PRO1291; B7h.5; B7X; B7S1; B7H4; B7-H4; immune costimulatory protein B7-H4; V-set domain-containing T-cell activation inhibitor 1; T-cell costimulatory molecule B7x; T cell costimulatory molecule B7x; B7 superfamily member 1; B7 family member, H4; V-set domain containing T cell activation inhibitor 1