BTNL2 (mouse):Fc (mouse) (rec.)

Catalog number: CHI-MF-110BTNL2-C100
Brand: Chimerigen Laboratories
Packing: 100 ug
Price: € 380.00
Expected delivery time: 7 days

Product specifications for - BTNL2 (mouse):Fc (mouse) (rec.)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: CHO cells
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis, to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.
Swiss prot ID: NP_524574.1
Additional information: 
Synonyms: CHI-MF-110BTNL2-C100; Chimerigen Laboratories; HSBLMHC1 / BTNL2; BTNL2; SS2; HSBLMHC1; BTL-II; butyrophilin-like protein 2; butyrophilin-like 2 (MHC class II associated)