CD134 [OX40] (human) (rec.) (His)

Catalog number: CHI-HR-200CD134-C025
Brand: Chimerigen Laboratories
Packing: 25 ug
Price: € 300.00
Expected delivery time: 7 days
Quantity:

Product specifications for - CD134 [OX40] (human) (rec.) (His)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Human
Properties: 
Purity: >97% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl.
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: CD134 (OX40) is a T cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumor necrosis factor receptor superfamily, which also includes the T cell antigen CD27, B cell antigen CD40, FAS antigen and the T cell activation antigen 4-1BB. The human CD134 protein is expressed only on activated CD4+ T blasts, and its ligand has been identified as gp34. Interactions between CD134 and its ligand in vivo are necessary for the differentiation of activated B cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B cells such as development of memory cells in the germinal centers. In addition, the CD134 and gp34 system directly mediate adhesion of activated T cells to vascular endothelial cells, and contribute to growth stimulation of the virus-infected T cells. - Protein. Human CD134 (aa 29-216) is fused at the C-terminus to a His-tag. Source: E. coli. Endotoxin content: <0.1EU/microg protein (LAL test; Lonza). Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl. Purity: >97% (SDS-PAGE). CD134 (OX40) is a T cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumor necrosis factor receptor superfamily, which also includes the T cell antigen CD27, B cell antigen CD40, FAS antigen and the T cell activation antigen 4-1BB. The human CD134 protein is expressed only on activated CD4+ T blasts, and its ligand has been identified as gp34. Interactions between CD134 and its ligand in vivo are necessary for the differentiation of activated B cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B cells such as development of memory cells in the germinal centers. In addition, the CD134 and gp34 system directly mediate adhesion of activated T cells to vascular endothelial cells, and contribute to growth stimulation of the virus-infected T cells.
Safety information: 
Hazard information: Non-hazardous
Additional information: 
Synonyms: CHI-HR-200CD134-C025; Chimerigen Laboratories