CD152 [CTLA-4] (human):Fc (human) (rec.) (non-lytic)

Catalog number: CHI-HF-220A4-M001
Brand: Chimerigen Laboratories
Packing: 1 mg
Other sizes: 100 ug
500 ug
Price: € 450.00
Expected delivery time: 7 days
Quantity:

Product specifications for - CD152 [CTLA-4] (human):Fc (human) (rec.) (non-lytic)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: CHO cells
Properties: 
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: CD152 (CTLA-4) and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
Swiss prot ID: NP_005205.2
Additional information: 
Synonyms: CHI-HF-220A4-M001; Chimerigen Laboratories; CTLA4 / CD152; CTLA4; IDDM12; GSE; GRD4; CTLA-4; CELIAC3; CD152; CD; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte antigen 4; cytotoxic T lymphocyte associated antigen 4 short spliced form; celiac disease 3; CD152 isoform; cytotoxic T-lymphocyte-associated protein 4