CD200 (human):Fc (human) (rec.) (non-lytic)

Catalog number: CHI-HF-220CD200-C100
Brand: Chimerigen Laboratories
Packing: 100 ug
Price: € 430.00
Expected delivery time: 7 days

Product specifications for - CD200 (human):Fc (human) (rec.) (non-lytic)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: CHO cells
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: CD200, also known as OX-2, is a 45 kDa transmembrane immunoregulatory protein that belongs to the immunoglobulin superfamily. CD200 is widely but not ubiquitously expressed. Its receptor (CD200R) is restricted primarily to mast cells, basophils, macrophages, and dendritic cells, which suggests myeloid cell regulation as the major function of CD200. CD200 knockout mice are characterized by increased macrophage number and activation and are predisposed to autoimmune disorders. In T cells, CD200 functions as a costimulatory molecule independent of the CD28 pathway. Several viruses encode CD200 homologs which are expressed on infected cells during the lytic phase. Like CD200 itself, viral CD200 homologs also suppress myeloid cell activity, enabling increased viral propagation.
Swiss prot ID: NP_005935.4
Additional information: 
Synonyms: CHI-HF-220CD200-C100; Chimerigen Laboratories; CD200; OX-2; MRC; MOX2; MOX1; antigen identified by monoclonal antibody MRC OX-2; OX-2 membrane glycoprotein; MRC OX-2 antigen; CD200 antigen; CD200 molecule