CD27 (human) (rec.) (His)

Catalog number: CHI-HR-200CD27-C050
Brand: Chimerigen Laboratories
Packing: 50 ug
Price: € 320.00
Expected delivery time: 7 days
Quantity:

Product specifications for - CD27 (human) (rec.) (His)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Human
Properties: 
Purity: >97% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl.
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis. - Protein. Human CD27 (aa 21-192) is fused at the C-terminus to a His-tag. Source: E. coli. Endotoxin content: <0.1EU/microg protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl. Purity: >97% (SDS-PAGE). CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.
Safety information: 
Hazard information: Non-hazardous
Additional information: 
Synonyms: CHI-HR-200CD27-C050; Chimerigen Laboratories