CD273 [PD-L2] (mouse):Fc (mouse) (rec.)

Catalog number: CHI-MF-110PDL2-C100
Brand: Chimerigen Laboratories
Packing: 100 ug
Price: € 350.00
Expected delivery time: 7 days

Product specifications for - CD273 [PD-L2] (mouse):Fc (mouse) (rec.)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: CHO cells
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1, CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
Swiss prot ID: NP_067371.1
Additional information: 
Synonyms: CHI-MF-110PDL2-C100; Chimerigen Laboratories; CD273 / PD-L2; PDCD1LG2; bA574F11.2; PDL2; PDCD1L2; PD-L2; CD273; Btdc; B7DC; programmed death ligand 2; butyrophilin B7-DC; PDCD1 ligand 2; PD-1-ligand 2; PD-1 ligand 2; B7-DC; B7 dendritic cell molecule; programmed cell death 1 ligand 2