CD274 [B7-H1/PD-L1] (mouse):Fc (mouse) (rec.) (non-lytic)

Product specifications for - CD274 [B7-H1/PD-L1] (mouse):Fc (mouse) (rec.) (non-lytic)

Overview:
Product group:	Proteins / Signaling Molecule
Category:	Proteins
Subcategory:	Recombinant protein
Source:	CHO cells

Properties:
Purity:	>98% (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352202
Form supplied:	Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions:	Store at -20°C

Scientific information:
Scientific info:	Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumor cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.
Swiss prot ID:	NP_068693.1

Scientific information:

Scientific info:

Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumor cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.

Swiss prot ID:

NP_068693.1

Additional information:
Synonyms:	CHI-MF-120PDL1-C100; Chimerigen Laboratories; PD-L1; Programmed Cell Death 1 Ligand Protein 1; PDCD1 Ligand 1; B7-H1; PDL1

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses: M.J. Butte, et al.; Immunity 27, 111 (2007)

Stimulation of the PD-1/PDL-1 T-cell co-inhibitory pathway is effective in treatment of experimental autoimmune glomerulonephritis: J. Reynolds, et al.; Nephrol. Dial. Transplant. 27, 1343 (2011)

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Product specifications for - CD274 [B7-H1/PD-L1] (mouse):Fc (mouse) (rec.) (non-lytic)