Bio-Connect

CD278 [ICOS] (mouse):Fc (mouse) (rec.)

Research Use Only
CHI-MF-110ICOS
Chimerigen Laboratories
Product group Proteins / Signaling Molecules
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Chimerigen Laboratories
  • Product Name
    CD278 [ICOS] (mouse):Fc (mouse) (rec.)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Scientific Description
    CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. - Protein. The extracellular domain of mouse CD278 [ICOS] (aa 21-142) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/microg protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in PBS. Purity: >98% (SDS-PAGE). CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352202