CD279 [PD-1] (mouse):Fc (human) (rec.)

Catalog number: CHI-MF-111PD1-C100
Brand: Chimerigen Laboratories
Packing: 100 ug
Price: € 350.00
Expected delivery time: 7 days
Quantity:

Product specifications for - CD279 [PD-1] (mouse):Fc (human) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Mouse
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: ~42kDa (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. - Protein. The extracellular domain of mouse CD279 [PD-1] (aa 26-169) is fused to the Fc region of human IgG1. Source: HEK 293 cells. Endotoxin: <0.06EU/microg. Lyophilized from 0.2microm-filtered solution in PBS. CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
Safety information: 
Hazard information: Non-hazardous
Additional information: 
Synonyms: CHI-MF-111PD1-C100; Chimerigen Laboratories