CD279 [PD-1] (mouse):Fc (mouse) (rec.)

Catalog number: CHI-MF-110PD1-C100
Brand: Chimerigen Laboratories
Packing: 100 ug
Price: € 335.00
Expected delivery time: 7 days
Quantity:

Product specifications for - CD279 [PD-1] (mouse):Fc (mouse) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Species: Mouse
Source: CHO cells
Properties: 
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
Swiss prot ID: NP_032824.1
Additional information: 
Synonyms: CHI-MF-110PD1-C100; Chimerigen Laboratories; PD-1; Programmed Cell Death Protein 1