CD40 (human):Fc (human) (rec.)

Catalog number: AG-40B-0083-3050
Brand: AdipoGen Life Sciences
Packing: 3 x 50 ug
Other sizes: 50 ug
Price: € 500.00
Expected delivery time: 7 days
Quantity:

Product specifications for - CD40 (human):Fc (human) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Human, Mouse
Target: CD40
Target description: CD40 molecule
Source: 293 Cells
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: ~54kDa (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 1 mg/ml
Form supplied: Lyophilized. Contains PBS.
Storage instructions: -20-¦C
Scientific information: 
Scientific info: CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. - Protein. The Fc portion of human IgG1 is fused to the C-terminus of human CD40 (aa 21-193). Source: HEK 293 cells. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds human and mouse CD40L. Purity: >95% (SDS-PAGE). CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
Gene ID: 958
Swiss prot ID: P25942
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDW40; p50; TNFRSF5; tumor necrosis factor receptor superfamily member 5