CD40 (human):Fc (human) (rec.)

Catalog number: CHI-HF-210CD40-C100
Brand: Chimerigen Laboratories
Packing: 100 ug
Price: € 430.00
Expected delivery time: 7 days

Product specifications for - CD40 (human):Fc (human) (rec.)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: CHO cells
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: CD40 is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 contains 4 cysteine-rich repeats in the extracellular domain and is expressed in B cells, dendritic cells, macrophages, endothelial cells and several tumor cell lines. The cognate interaction between CD40 and CD40 ligand (CD154) on T cells activates NF-kappaB, Jun N-terminal kinase and Janus kinase signal transducers and activators of transcription pathways. Several different TRAF proteins (adapter proteins) have been identified to serve as mediators of the signal transduction. In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation and thus is thought to be an early event in Alzheimer disease pathogenesis. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by the inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response and a lack of germinal center formation.
Swiss prot ID: AAH12419.1
Additional information: 
Synonyms: CHI-HF-210CD40-C100; Chimerigen Laboratories; CD40; p50; TNFRSF5; CDW40; Bp50; tumor necrosis factor receptor superfamily, member 5; tumor necrosis factor receptor superfamily member 5; nerve growth factor receptor-related B-lymphocyte activation molecule; CD40L receptor; CD40 type II isoform; CD40 antigen (TNF receptor superfamily member 5); B-cell surface antigen CD40; B cell-associated molecule; B cell surface antigen CD40; CD40 molecule, TNF receptor superfamily member 5