CD40L [CD154] (human)-muCD8 Fusion Protein

Catalog number: ANC-505-020
Brand: Ancell Corporation
Packing: 25 ug
Price: € 460.00
Expected delivery time: 7 days

Product specifications for - CD40L [CD154] (human)-muCD8 Fusion Protein

Product group: Proteins / Signaling Molecule
Category: Chemokines / cytokines
Source: CHO cells
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate
Storage instructions: Store at +4°C
Scientific information: 
Scientific info: Human CD154 (CD40 ligand) is a member of the TNF family and is expressed on the surface of activated T cells. It can undergo proteolytic cleavage into a 19kDa immunologically active soluble form. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function. Increased levels of CD154 has been associated with autoimmune disorders including SLE, CLL and eosinophilic fasciitis. CD154 has been reported to be expressed on vascular endothelial cells, smooth muscle cells, macrophages and activated platelets indicating a role for the CD40-CD154 immunoregulatory signaling in artherosclerosis and cardiovascular disorders.
Additional information: 
Synonyms: ANC-505-020; Ancell Corporation; CD40LG / CD54; CD40LG; hCD40L; gp39; TRAP; TNFSF5; T-BAM; IMD3; IGM; HIGM1; CD40L; CD154; tumor necrosis factor (ligand) superfamily member 5; TNF-related activation protein; T-cell antigen Gp39; T-B cell-activating molecule; CD40-L; CD40 antigen ligand; CD40 ligand