CD40L [CD154] (human):Fc (human) (rec.)

Catalog number: CHI-HF-210CD40L-C050
Brand: Chimerigen Laboratories
Packing: 50 ug
Price: € 300.00
Expected delivery time: 7 days

Product specifications for - CD40L [CD154] (human):Fc (human) (rec.)

Product group: Proteins / Signaling Molecule
Category: Chemokines / cytokines
Source: CHO cells
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kDa type II transmembrane glycoprotein that belongs to the TNF superfamily. As with other TNF superfamily members, CD40L will exist as a trimer, both as a membrane bound and soluble form. Multiple mutations and alternate splice forms of CD40L exist, often associated with pathology and leading to truncated or nontrimerizable forms of CD40L. CD40L binds to both CD40 and to integrin alphaIIbbeta3 (CD41). In the cell membrane, it also associates with a unique splice variant of CD28 (CD28i) that may facilitate CD40L signal transduction. CD40L is expressed by monocytes, NK cells, mast cells, basophils, smooth muscle cells, endothelial cells, dendritic cells,activated and resting B cells, plus activated platelets and CD4+ T cells. CD40L ligation of CD40 on dendritic cells (DC) initiates DC maturation and differentiation. CD40L signaling into naive B cells promotes germinal center formation and isotope switching. CD40-CD40L seems to bridge innate and adaptive immune signals.
Swiss prot ID: NP_000065.1
Additional information: 
Synonyms: CHI-HF-210CD40L-C050; Chimerigen Laboratories; CD40LG / CD54; CD40LG; hCD40L; gp39; TRAP; TNFSF5; T-BAM; IMD3; IGM; HIGM1; CD40L; CD154; tumor necrosis factor (ligand) superfamily member 5; TNF-related activation protein; T-cell antigen Gp39; T-B cell-activating molecule; CD40-L; CD40 antigen ligand; CD40 ligand