CD40L (human) (multimeric) (rec.)

Catalog number: AG-40B-0010-C010
Brand: AdipoGen Life Sciences
Packing: 10 ug
Other sizes: 3 x 10 ug
Price: € 310.00
Expected delivery time: 7 days

Product specifications for - CD40L (human) (multimeric) (rec.)

Product group: Proteins / Signaling Molecule
Category: Chemokines / cytokines
Source: CHO cells
Purity: >95% (SDS-PAGE)
Molecular weight: 35-40 kDa
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 0.1mg/ml after reconstitution.
Form supplied: Lyophilized. Contains PBS
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: MultimericCD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to combinations. MultimericCD40L has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
Swiss prot ID: P29965
Safety information: 
Additional information: 
Synonyms: AG-40B-0010-C010; AdipoGen Life Sciences; ACRP30headless:CD40L; ACRP30headless:CD154; ACRP30headless:TNFSF5; ADIPOQ-CD40L
IgG subclass switch capacity is low in switched and in IgM-only, but high in IgD+IgM+, post-germinal center (CD27+) human B cells: C. Werner-Favre, et al.; Eur. J. Immunol. 31, 243 (2001) Read more
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex: N. Holler, et al.; Mol. Cell. Biol. 23, 1428 (2003) Read more
Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sezary syndrome: circumvention by hexameric soluble CD40L: L.E. French, et al.; Blood 105, 219 (2005) Read more
Cysteine-rich Domain 1 of CD40 Mediates Receptor Self-assembly: C.R. Smulski, et al.; J. Biol. Chem. 288, 10914 (2013) Read more
Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay: H.B. Larman, et al.; Nucl. Acids Res. 42, 9146 (2014) Read more
CD4+ T Cell-derived IL-21 and deprivation of CD40 signaling favor the In Vivo development of granzyme B-expressing regulatory B cells in HIV patients: C. Kaltenmeier, et al.; J. Immunol. 194, 3768 (2015) Read more