CD40L (rat) (multimeric) (rec.)

Catalog number: AG-40B-0107-C010
Brand: AdipoGen Life Sciences
Packing: 10 ug
Other sizes: 3 x 10 ug
Price: € 300.00
Expected delivery time: 7 days
Quantity:

Product specifications for - CD40L (rat) (multimeric) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Human, Mouse, Rat
Target: Cd40lg
Target description: CD40 ligand
Source: CHO Cells
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: ~35-40kDa
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 0.1 mg/ml
Form supplied: Lyophilized. Contains PBS.
Storage instructions: -20-¦C
Scientific information: 
Scientific info: MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L™ has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced. - Protein. Rat CD40L (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag. Source: CHO cells. Endotoxin content: <0.02EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to rat, human and mouse CD40. Purity: >95% (SDS-PAGE). MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L™ has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
Gene ID: 84349
Swiss prot ID: Q9Z2V2
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: CD40 ligand; CD40 ligand CD154; Cd40l; CD40-L; Tnfsf5; tumor necrosis factor ligand superfamily member 5