CF53 [1808160-52-2]
HY-112610
CAS Number1808160-52-2
Product group Chemicals
Estimated Purity98.94%
Molecular Weight443.5
Overview
- SupplierMedChem Express
- Product NameCF53 [1808160-52-2]
- Delivery Days Customer10
- CAS Number1808160-52-2
- Estimated Purity98.94%
- Molecular FormulaC24H25N7O2
- Molecular Weight443.5
- Scientific DescriptionCF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo.
- SMILESCOC1=C(C2=C(C)ON=C2C)C=C(NC3=C4C(NC5=CC(C6CC6)=NN5C)=NC(C)=N3)C4=C1
- Storage Instruction-20°C,-80°C
- UNSPSC12352200