GITRL, Soluble (mouse) (rec.)

Catalog number: AG-40A-0008-C050
Brand: AdipoGen Life Sciences
Packing: 50 ug
Price: € 300.00
Expected delivery time: 7 days
Quantity:

Product specifications for - GITRL, Soluble (mouse) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Mouse
Target: Tnfsf18
Target description: tumor necrosis factor (ligand) superfamily, member 18
Source: 293 Cells
Properties: 
Purity: >90% (SDS-PAGE)
Molecular weight: ~22kDa (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 0.5 mg/ml
Form supplied: Liquid. 0.2um-filtered solution in 10mM glycine, pH 10.0.
Storage instructions: -20-¦C
Scientific information: 
Scientific info: GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors. - Protein. The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.1EU/microg purified protein (LAL test; Lonza). Liquid. 0.2microm-filtered solution in 10mM glycine, pH 10.0. Binds to mouse GITR. Purity: >90% (SDS-PAGE). GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Gene ID: 240873
Swiss prot ID: Q7TS55
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: GITR ligand; Gitrl; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced-tumor necrosis factor receptor ligand; Tnlg2a; tumor necrosis factor ligand 2a; tumor necrosis factor ligand superfamily member 18
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells: K.Y. Yu, et al.; BBRC 310, 433 (2003) Read more