GITRL, Soluble (mouse) (rec.)

Catalog number: AG-40A-0008-C050
Brand: AdipoGen Life Sciences
Packing: 50 ug
Price: € 300.00
Expected delivery time: 7 days

Product specifications for - GITRL, Soluble (mouse) (rec.)

Product group: Proteins / Signaling Molecule
Category: Chemokines / cytokines
Source: HEK 293 cells
Purity: >90% (SDS-PAGE)
Molecular weight: 22 kDa
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 0.5mg/ml
Form supplied: Liquid. 0.2um-filtered solution in 10mM glycine, pH 10.0.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Swiss prot ID: Q7TS55
Safety information: 
Additional information: 
Synonyms: AG-40A-0008-C050; AdipoGen Life Sciences; Glucocorticoid-induced TNF Receptor Ligand; AITRL; Activation-inducible TNF-related Ligand; TNFSF18
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells: K.Y. Yu, et al.; BBRC 310, 433 (2003) Read more