HMGB1 (rat):Fc (human) (rec.)

Catalog number: CHI-RF-311HMGB1-C050
Brand: Chimerigen Laboratories
Packing: 50 ug
Price: € 410.00
Expected delivery time: 7 days

Product specifications for - HMGB1 (rat):Fc (human) (rec.)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: CHO cells
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
Swiss prot ID: NP_037095.1
Additional information: 
Synonyms: CHI-RF-311HMGB1-C050; Chimerigen Laboratories; HMG1 / HMGB1; HMGB1; SBP-1; HMG3; HMG1; high-mobility group box 1; high-mobility group (nonhistone chromosomal) protein 1; high mobility group protein B1; high mobility group protein 1; Sulfoglucuronyl carbohydrate binding protein; HMG-1; Amphoterin; high mobility group box 1