Human C5a protein
ORB545722
Product group Proteins / Signaling Molecules
Overview
- SupplierBiorbyt
- Product NameHuman C5a protein
- Delivery Days Customer16
- Applications SupplierSDS-PAGE
- CertificationResearch Use Only
- Estimated Purity>90%
- Scientific DescriptionDerived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
- Storage Instruction-20°C
- UNSPSC12352202