Human DCK / Deoxycytidine kinase Protein (Recombinant His)

LifeSpan BioSciences

Human DCK / Deoxycytidine kinase Protein (Recombinant His)

23

Research Use Only

0.5 mg/ml

>90%

DCK is a key enzyme in the salvage of deoxyribonucleosides and in the activation of clinically relevant nucleoside analogues. This protein is responsible for the 5-phosphorylation of purine and pyrimidine deoxynucleosides to the corresponding monophosphates using ATP or uTP as phosphate donors. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. Recombinant human DCK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

2°C to 8°C,-20°C or -80°C

12352202