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Human FGF-23 protein

Research Use Only
ORB107724
Biorbyt
Product group Proteins / Signaling Molecules
Price on request
Packing Size
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Overview

  • Supplier
    Biorbyt
  • Product Name
    Human FGF-23 protein
  • Delivery Days Customer
    16
  • Applications Supplier
    HPLC, SDS-PAGE
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Scientific Description
    Fibroblast growth factor-23 (FGF-23) belongs to the large FGF family which has at least 23 members. All FGF family membersare heparin binding growth factors with a core 120 amino acid (a.a.) FGF domain that allows for a common tertiary structure.FGFs are expressed during embryonic development and in restricted adult tissues. Four distinct but related classes of FGFreceptors, FGF R1, 2, 3, and 4, exist. FGF-23 is produced by osteocytes and osteoblasts in response to high circulating phosphatelevels, elevated parathyroid hormone, and circulatory volume loading. It functions as an endocrine phosphatonin by suppressingcirculating phosphate levels. FGF-23 interaction with renal proximal tubular epithelium decreases the renal resorption ofphosphate by down regulating phosphate transporters and by suppressing vitamin D production. It also decreases the intestinalabsorption of phosphate.
  • Source
    E.coli
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352202