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GTX67440-pro Image
GTX67440-pro Image
GTX67440-pro Image

Human GSTM4 protein

Research Use Only
GTX67440-PRO
GeneTex
Product group Molecular Biology
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    Human GSTM4 protein
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Scientific Description
    Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq, Jul 2008]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    41116133