Human IL-36 gamma (152a.a.) protein

Biorbyt

Human IL-36 gamma (152a.a.) protein

16

HPLC, SDS-PAGE

Research Use Only

>95%

Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36G, IL-36H, and IL-36D (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptorfamily members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36D is secreted when transfected into 293-T cells and it could constitutepart of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1receptor type I (IL-1R1). Furthermore, IL-36D also can function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Human IL-36D (152a.a) shares 58 %, 59 %, 68 % and 69 % a.a. sequence identity with mouse, rat,bovine and equine IL-36D, respectively, and 23 - 57% a.a. sequence identity with other family members.

E.coli

2°C to 8°C,-20°C

12352202