Human IL-36RA protein

Biorbyt

Human IL-36RA protein

16

HPLC, SDS-PAGE

Research Use Only

>95%

Interleukin-36 receptor antagonist (IL-36RA) is a secreted protein which belongs to the interleukin 1 cytokine family (IL-1family) and it is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RA hasbeen reported to antagonize the biological activity of IL-36G (IL-1F6), IL-36H (IL-1F8), and IL-36I (IL-1F9). Furthermore, itcould constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonistand interleukin-1 receptor type I (IL-1R1). In addition, The receptor for IL-36RA has not been positively identified. Indirectevidence suggests it is IL-1Rrp2. Recombinant human IL-36 RA contains 154 amino acid residues and it shares 91 % a.a.sequence identity with murine IL-36RA.

E.coli

2°C to 8°C,-20°C

12352202