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GTX67958-pro Image
GTX67958-pro Image
GTX67958-pro Image

Human MAFK protein

Research Use Only
GTX67958-PRO
GeneTex
Protein IDO60675
Product group Proteins / Signaling Molecules
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    Human MAFK protein
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Concentration
    0.5 mg/ml
  • Protein IDO60675
  • Protein Name
    Transcription factor MafK
  • Scientific Description
    The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352202