Bio-Connect

Human Nectin-3 protein

Research Use Only
ORB348806
Biorbyt
Product group Proteins / Signaling Molecules
Price on request
Packing Size
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Overview

  • Supplier
    Biorbyt
  • Product Name
    Human Nectin-3 protein
  • Delivery Days Customer
    16
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Scientific Description
    Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352202