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GTX00211-pro Image
GTX00211-pro Image
GTX00211-pro Image

Human TGF beta 2 protein (active)

Research Use Only
GTX00211-PRO
GeneTex
ApplicationsFunctional Assay
Product group Proteins / Signaling Molecules
Protein IDP61812
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    Human TGF beta 2 protein (active)
  • Delivery Days Customer
    10
  • Applications
    Functional Assay
  • Certification
    Research Use Only
  • Protein IDP61812
  • Protein Name
    Transforming growth factor beta-2
  • Scientific Description
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352202