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GTX00110-pro Image
GTX00110-pro Image
GTX00110-pro Image

Human VEGF165 protein (active)

Research Use Only
GTX00110-PRO
GeneTex
ApplicationsFunctional Assay
Product group Proteins / Signaling Molecules
Protein IDP15692
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    Human VEGF165 protein (active)
  • Delivery Days Customer
    10
  • Applications
    Functional Assay
  • Certification
    Research Use Only
  • Protein IDP15692
  • Protein Name
    Vascular endothelial growth factor A
  • Scientific Description
    This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352202