hVEGF-IN-1 [1637443-98-1]

MedChem Express

hVEGF-IN-1 [1637443-98-1]

10

1637443-98-1

Research Use Only

99.26%

C34H43N7O2

581.75

hVEGF-IN-1, a quinazoline derivative, could specifically bind to the G-rich sequence in the internal ribosome entry site A (IRES-A) and destabilize the G-quadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 microM in SPR experiments. hVEGF-IN-1 could hinder tumor cells migration and repress tumor growth by decreasing VEGF-A protein expression.

CCN(CC)CCOC(C=C1)=CC=C1NC2=NC(C3=C(NC(CCN4CCN(C)CC4)=O)C=CC=C3)=NC5=CC=CC=C52

2°C to 8°C,-20°C,-80°C

12352200