IL-2 (mouse):Fc (mouse) (rec.) (non-lytic)

Catalog number: CHI-MF-12002-C010
Brand: Chimerigen Laboratories
Packing: 10 ug
Other sizes: Other sizes available
Price: On Request
Expected delivery time: 7 days
Quantity:

Product specifications for - IL-2 (mouse):Fc (mouse) (rec.) (non-lytic)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Chemokines / cytokines
Species: Mouse
Properties: 
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens. - Protein. The extracellular domain of mouse IL-2 (aa 21-169) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a. Source: NS1 cells. Endotoxin content: <0.06EU/microg protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in PBS. Purity: >98% (SDS-PAGE). Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
Safety information: 
Hazard information: Non-hazardous
Additional information: 
Synonyms: CHI-MF-12002-C010; Chimerigen Laboratories
Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation: X.X. Zheng, et al.; J. Immunol. 154, 5590 (1995) Read more
Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration: D.H. Barouch, et al.; J. Immunol. 161, 1875 (1998) Read more
IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice: X.X. Zheng, et al.; J. Immunol. 163, 4041 (1999) Read more
Effects of Cyclosporine on Transplant Tolerance: The Role of IL-2: X.X. Zheng, et al.; Am. J. Transplant. 7, 1907 (2007) Read more
Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response: O. Feinerman, et al.; Mol. Sys. Biol. 6, 437 (2010) Read more