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Jagged-2 (human):Fc (human) (rec.)

Research Use Only
AG-40A-0155Y
AdipoGen Life Sciences
Protein IDQ9Y219
Product group Proteins / Signaling Molecules
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Jagged-2 (human):Fc (human) (rec.)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Concentration
    0.1 mg/ml
  • Estimated Purity
    >90%
  • Protein IDQ9Y219
  • Protein Name
    Protein jagged-2
  • Scientific Description
    Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development. - Protein. Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG. Source: HEK 293 cells. Endotoxin content: <0.1EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS + 0.02 % CHAPS. Purity: >90% (SDS-PAGE). Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352202