Onametostat [2086772-26-9]

MedChem Express

Onametostat [2086772-26-9]

10

2086772-26-9

98.56%

C22H23BrN6O2

483.36

Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.14 nM. Onametostat has potent activity in lung cancer.

BrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1

2°C to 8°C,-20°C,-80°C

12352200