LAG-3 (human):Fc (human) (rec.)

Catalog number: AG-40B-0031-C050
Brand: AdipoGen Life Sciences
Packing: 50 ug
Price: € 320.00
Expected delivery time: 7 days

Product specifications for - LAG-3 (human):Fc (human) (rec.)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: CHO cells
Purity: >99% (SDS-PAGE)
Molecular weight: 80 kDa
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 0.5 mg/ml
Form supplied: Liquid. In PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Swiss prot ID: P18627
Safety information: 
Additional information: 
Synonyms: AG-40B-0031-C050; AdipoGen Life Sciences; Lymphocyte Activation Gene-3; FDC Protein; CD223
CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins: B. Huard, et al.; Eur. J. Immunol. 25, 2718 (1995) Read more
T cell major histocompatibility complex class II molecules down-regulate CD4+ T cell clone responses following LAG-3 binding: B. Huard, et al.; Eur. J. Immunol. 26, 1180 (1996) Read more
Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223): S. Andreae, et al.; J. Immunol. 168, 3874 (2002) Read more
LAG-3 (CD223) reduces macrophage and dendritic cell differentiation from monocyte precursors: S. Buisson & F. Triebel; Immunology 114, 369 (2005) Read more
A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors: F. Triebel, et al.; Cancer Lett. 235, 147 (2006) Read more
A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells: C. Brignone, et al.; J. Immunol. 179, 4202 (2007) Read more