Murine PF-4 protein

Biorbyt

Murine PF-4 protein

16

HPLC, SDS-PAGE

Research Use Only

>97%

Platelet Factor 4, is a member of the CXC chemokine family, CXCL4. CXCL4 has homology with IL8 and beta thromboglobulin.The active protein consists of a tetramer composed of individual CXCL4 subunits. Megakaryocytes synthesize CXCL4 and storeit as tetramers in alpha -granules. The CXCL4 tetramers are secreted by activated platelets and can be measured at micromolar levelsin serum. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes. CXCL4does not contain an ELR motif. However, many other functions have been observed for CXCL4. CXCL4 is involved in monocytesurvivial and differentiation into macrophages, and it has antiangiogenic activity. CXCL4 has been demonstrated to inhibit thebinding of FGF2 to highaffinity receptors and its subsequent internalization. Cell surface neutrophil chondroitin sulfate chainsserve as CXCL4 binding sites; affinity is controlled by the degree of sulfation of these chains.

E.coli

2°C to 8°C,-20°C

12352202