Murine TARC protein

Biorbyt

Murine TARC protein

16

HPLC, SDS-PAGE

Research Use Only

>97%

Thymus and activation regulated chemokine (TARC) is a novel CC chemokine, also called CCL17, recently identified using asignal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (a.a.) residue precursor protein with a 23 a.a.residue signal peptide that is cleaved to generate the 71 a.a. residue mature secreted protein. Among CC chemokine familymembers, CCL17 has approximately 24 - 29% amino acid sequence identity with RANTES, MIP-1D, MIP-1E, MCP-1, MCP-2,MCP-3 and I-309. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to bechemotactic for T cell lines but not monocytes or neutrophils. CCL17 was recently identified to be a specific functional ligand forCCR-4, a receptor that is selectively expressed on T cells.

E.coli

2°C to 8°C,-20°C

12352202