Netrin-1 (human):Fc (human) (rec.)

Catalog number: AG-40B-0075-C010
Brand: AdipoGen Life Sciences
Packing: 10 ug
Other sizes: Other sizes available
Price: € 310.00
Expected delivery time: 7 days
Quantity:

Product specifications for - Netrin-1 (human):Fc (human) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Human, Mouse, Rat
Target: NTN1
Target description: netrin 1
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: ~90kDa (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 0.1 mg/ml
Form supplied: Lyophilized. Contains PBS plus protein stabilizer. No BSA included. The protein stabilizer shows no interference with protein activity.
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b. - Protein. Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.1EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS plus protein stabilizer. No BSA included. The protein stabilizer shows no interference with protein activity. Binds to human, mouse and rat UNC5B. Purity: >95% (SDS-PAGE). Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.
Gene ID: 9423
Swiss prot ID: O95631
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-40B-0075-C010; AdipoGen Life Sciences; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of; netrin-1; NTN1L
DCC constrains tumour progression via its dependence receptor activity: M. Castets, et al.; Nature 482, 534 (2011) Read more
The amyloid precursor protein regulates netrin-1 mediated commissural axon outgrowth: N. Rama, et al.; J. Biol. Chem. 287, 30014 (2012) Read more
Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance: D. Ozmadenci, et al.; Nat. Commun. 6, ID7398 (2015) Read more