OX40 (human):Fc (human) (rec.)

Catalog number: AG-40B-0014-C050
Brand: AdipoGen Life Sciences
Packing: 50 ug
Other sizes: 3 x 50 ug
Price: € 180.00
Expected delivery time: 7 days
Quantity:

Product specifications for - OX40 (human):Fc (human) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Human, Mouse
Target: TNFRSF4
Target description: TNF receptor superfamily member 4
Source: 293 Cells
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: ~70kDa (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 1 mg/ml
Form supplied: Lyophilized. Contains PBS.
Storage instructions: -20-¦C
Scientific information: 
Scientific info: OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully. - Protein. Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse OX40L. Purity: >95% (SDS-PAGE). OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.
Gene ID: 7293
Swiss prot ID: P43489
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: ACT35; ACT35 antigen; ATC35 antigen; CD134; CD134 antigen; IMD16; lymphoid activation antigene ACT35; OX40; OX40 antigen; OX40 cell surface antigen; OX40 homologue; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor; tumor necrosis factor receptor superfamily member 4; TXGP1L