OX40L (mouse) (multimeric) (rec.)

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Product specifications for - OX40L (mouse) (multimeric) (rec.)

Overview:
Product group:	Proteins / Signaling Molecule
Category:	Proteins
Species:	Human, Mouse
Target:	Tnfsf4
Target description:	tumor necrosis factor (ligand) superfamily, member 4
Source:	293 Cells

Properties:
Purity:	>90% (SDS-PAGE)
Molecular weight:	~40kDa (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352202
Concentration:	0.1 mg/ml
Form supplied:	Lyophilized. Contains PBS.
Storage instructions:	-20-¦C

Scientific information:
Scientific info:	OX40L is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its ligand OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. MultimericOX40L is a high activity construct in which two trimeric OX40L ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively activates T cell proliferation. - Protein. The extracellular domain of mouse OX40L (aa 52-199) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse OX40 [CD134]. Purity: >90% (SDS-PAGE). OX40L is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its ligand OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. MultimericOX40L is a high activity construct in which two trimeric OX40L ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively activates T cell proliferation.
Gene ID:	22164
Swiss prot ID:	P43488

Safety information:
MSDS:	MSDS

Additional information:
Synonyms:	Ath1; Ath-1; atherosclerosis 1; CD134L; gp34; OX40 ligand; Ox40l; OX-40L; tax-transcriptionally activated glycoprotein 1 ligand; Tnlg2b; tumor necrosis factor ligand 2b; tumor necrosis factor ligand superfamily member 4; TXGP1; Txgp1l

Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA: J. Mestas, et al.; Int. Immun. 17, 737 (2005)

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Product specifications for - OX40L (mouse) (multimeric) (rec.)