PARP-1 [ARTD1] (human) (rec.) (His) (high purity)

Catalog number: AG-40T-0011-C010
Brand: AdipoGen Life Sciences
Packing: 10 ug
Price: € 280.00
Expected delivery time: 7 days

Product specifications for - PARP-1 [ARTD1] (human) (rec.) (His) (high purity)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: Sf21 cells
Purity: >98% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: Lot dependent (0.2-0.5mg/ml)
Form supplied: Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.
Storage instructions: Store at -80°C
Scientific information: 
Scientific info: PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Swiss prot ID: P09874
Safety information: 
Additional information: 
Synonyms: AG-40T-0011-C010; AdipoGen Life Sciences; Poly(ADP-ribose) Polymerase 1; ADP-ribosyltransferase Diphtheria Toxin-like 1; NAD(+) ADP-ribosyltransferase 1
Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1: P.O. Hassa, et al.; J. Biol. Chem. 278, 45145 (2003) Read more
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription: P.O. Hassa, et al.; J. Biol. Chem. 280, 40450 (2005) Read more