Rat FGF-21 protein

Biorbyt

Rat FGF-21 protein

16

HPLC, SDS-PAGE

Research Use Only

>95%

Fibroblast growth factor 21 (FGF-21) encoded by the FGF-21 gene belongs to the large FGF family and it is specifically inducedby HMGCS2 activity. In mice, brown adipose tissue becomes a source of systemic FGF-21 after cold exposure. FGF-21stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (butnot SLC2A4/GLUT4 expression) and the activity depends on the presence of KLB. Recombinant rat FGF-21 contains 180 aminoacids residues and show limited binding to heparin. In addition, rat FGF-21 respectively shows 81 % and 92 % a.a. identity tohuman and murine FGF-21, and it show activity on murine and human cells.

E.coli

2°C to 8°C,-20°C

12352202