Rat IL-33 protein

Biorbyt

Rat IL-33 protein

16

HPLC, SDS-PAGE

Research Use Only

>95%

Interleukin-33 (IL-33), also known as NF-HEV and DVS 27, is a cytokine belonging to the IL-1 superfamily. It is also aproinflammatory protein that may regulate gene transcription and it induces helper T cells, mast cells, eosinophils and basophilsto produce type 2 cytokines. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathologicalchanges observed in mucosal organs following administration of IL-33. IL-33 is constitutively expressed in smooth muscle andairway epithelia and it binds to a high-affinity receptor family member ST2. In vivo administration of mature IL-33 promotesincreased production of IL-5, IL-13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues.Recombinant rat IL-3 contains 156 amino acid residues and it shares 59 % a.a. and 90 % sequence identity with human andmurine IL-33.

E.coli

2°C to 8°C,-20°C

12352202