SGC-iMLLT [2255338-25-9]

MedChem Express

SGC-iMLLT [2255338-25-9]

10

2255338-25-9

95%

C22H24N6O

388.47

SGC-iMLLT is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC50 of 0.26 microM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with Kds of 0.129 and 0.077 microM, respectively.

CN1N=CC2=CC(C(NC3=CC=C(NC(CN4[C@@H](C)CCC4)=N5)C5=C3)=O)=CC=C21

2°C to 8°C,-20°C,-80°C

12352200