Taminadenant [1337962-47-6]

MedChem Express

Taminadenant [1337962-47-6]

10

1337962-47-6

99.46%

C10H8BrN7

306.12

Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response.

BrC(C(N1C=CC=N1)=NC(N2C=CC=N2)=N3)=C3N

2°C to 8°C,-20°C,-80°C

12352200