TNF-alpha (mouse) (multimeric) (rec.)

Catalog number: AG-40B-0021-C010
Brand: AdipoGen Life Sciences
Packing: 10 ug
Other sizes: 3 x 10 ug
Price: € 180.00
Expected delivery time: 7 days
Quantity:

Product specifications for - TNF-alpha (mouse) (multimeric) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Chemokines / cytokines
Species: Human, Mouse
Target: Tnf
Target description: tumor necrosis factor
Source: 293 Cells
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: ~34kDa (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 0.1 mg/ml
Form supplied: Lyophilized. Contains PBS.
Storage instructions: -20°C
Scientific information: 
Scientific info: Protein. The extracellular domain of mouse TNF-alpha (aa 77-235) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.02EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse TNF-R1 and TNF-R2. Purity: >95% (SDS-PAGE). Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (TNF-alpha (mouse) (multimeric) (rec.) (Prod. No. AG-40B-0021). Since the MultimericTNF-alpha™ mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either normal TNF-alpha or MultimericTNF-alpha™ can be used. - Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (TNF-alpha (mouse) (multimeric) (rec.) (Prod. No. AG-40B-0021). Since the MultimericTNF-alpha™ mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either normal TNF-alpha or MultimericTNF-alpha™ can be used.
Gene ID: 21926
Swiss prot ID: P06804
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: cachectin; DIF; Tnfa; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; Tnlg1f; tumor necrosis factor; tumor necrosis factor ligand 1f; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha