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VISTA [B7-H5] (human) (rec.) (His)

Research Use Only
AG-40B-0177
AdipoGen Life Sciences
Protein IDQ9H7M9
Product group Proteins / Signaling Molecules
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    VISTA [B7-H5] (human) (rec.) (His)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Concentration
    0.1 mg/ml
  • Estimated Purity
    >95%
  • Protein IDQ9H7M9
  • Protein Name
    V-type immunoglobulin domain-containing suppressor of T-cell activation
  • Scientific Description
    Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on antigen presenting cells (APC) delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. - Protein. The extracellular domain of human VISTA (B7-H5) (aa 33-194) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Endotoxin: <0.01EU/microg. Lyophilized. Contains PBS. Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on antigen presenting cells (APC) delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352202