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VISTA [B7-H5] (human) (rec.) (His)
Catalog number:
AG-40B-0177-C010
Brand:
AdipoGen Life Sciences
Packing:
10 ug
Other sizes:
Other sizes available
Price:
€ 145.00
Expected delivery time:
7 days
Quantity:
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General
Product specifications for - VISTA [B7-H5] (human) (rec.) (His)
Overview:
Product group:
Proteins / Signaling Molecule
Category:
Proteins
Species:
Human
Target:
VSIR
Target description:
V-set immunoregulatory receptor
Properties:
Purity:
>95% (SDS-PAGE)
Molecular weight:
~30-40kDa (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352202
Concentration:
0.1 mg/ml
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on antigen presenting cells (APC) delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. - Protein. The extracellular domain of human VISTA (B7-H5) (aa 33-194) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Endotoxin: <0.01EU/microg. Lyophilized. Contains PBS. Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on antigen presenting cells (APC) delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.
Gene ID:
64115
Swiss prot ID:
Q9H7M9
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
AG-40B-0177-C010; AdipoGen Life Sciences; B7H5; B7-H5; C10orf54; DD1alpha; Death Domain1alpha; GI24; PD-1H; PDCD1 homolog; platelet receptor GI24; PP2135; sisp-1; SISP1; stress-induced secreted protein-1; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation