VISTA [B7-H5] (human) (rec.) (His)

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Product specifications for - VISTA [B7-H5] (human) (rec.) (His)

Overview:
Product group:	Proteins / Signaling Molecule
Category:	Proteins
Species:	Human
Target:	VSIR
Target description:	V-set immunoregulatory receptor

Properties:
Purity:	>95% (SDS-PAGE)
Molecular weight:	~30-40kDa (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352202
Concentration:	0.1 mg/ml
Storage instructions:	2-¦C to 8-¦C, -20-¦C

Scientific information:
Scientific info:	Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on antigen presenting cells (APC) delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. - Protein. The extracellular domain of human VISTA (B7-H5) (aa 33-194) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Endotoxin: <0.01EU/microg. Lyophilized. Contains PBS. Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on antigen presenting cells (APC) delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.
Gene ID:	64115
Swiss prot ID:	Q9H7M9

Safety information:
MSDS:	MSDS
Hazard information:	Non-hazardous

Additional information:
Synonyms:	AG-40B-0177-C010; AdipoGen Life Sciences; B7H5; B7-H5; C10orf54; DD1alpha; Death Domain1alpha; GI24; PD-1H; PDCD1 homolog; platelet receptor GI24; PP2135; sisp-1; SISP1; stress-induced secreted protein-1; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation

Additional information:

Synonyms:

AG-40B-0177-C010; AdipoGen Life Sciences; B7H5; B7-H5; C10orf54; DD1alpha; Death Domain1alpha; GI24; PD-1H; PDCD1 homolog; platelet receptor GI24; PP2135; sisp-1; SISP1; stress-induced secreted protein-1; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation

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Product specifications for - VISTA [B7-H5] (human) (rec.) (His)