VISTA [B7-H5] (mouse):Fc (human) (rec.)

Catalog number: AG-40B-0164-C050
Brand: AdipoGen Life Sciences
Packing: 50 ug
Price: € 290.00
Expected delivery time: 7 days

Product specifications for - VISTA [B7-H5] (mouse):Fc (human) (rec.)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: HEK 293 cells
Purity: >95% (SDS-PAGE)
Molecular weight: 65-70 kDa
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 1mg/ml after reconstitution.
Form supplied: Lyophilized. Contains PBS.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Mouse VISTA is a 55- to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.
Swiss prot ID: Q9D659
Safety information: 
Additional information: 
Synonyms: AG-40B-0164-C050; AdipoGen Life Sciences